<zaman_2756@[EMAIL PROTECTED]
> wrote in message
news:f50436e0-464a-42b9-800e-b08cc1f2e780@[EMAIL PROTECTED]
> On 10 Nov, 15:56, MobiusDick <MobiusD...@[EMAIL PROTECTED]
> wrote:
>> There are very scientific reasons why lower percentagealcohollike
>> wine or beer gives more of a euphoria than higher percentagealcohol
>> like liquor and spirits, particularly in non-alcoholics. The rate of
>> absorbtion of thealcoholfrom the stomach as well as the amount of
>> the primary metabolite, acetaldehyde, are both primary factors
>> involved inalcohol'seuphoriant effects.
>>
>> Whenalcoholis absorbed slowly from the stomach, the desired
>> bloodalcoholconcentration is often achieved more readily. Absorb too
much
>> too quickly, and the effects ofalcoholcan be very different, causing
>> more of a sedative effect and less of a euphoriant effect.Alcoholhas
>> multiple modes of action, and one of them is receptor driven at the
>> GABA-A receptor complex (which is also where benzodiazepines and
>> barbiturates work-although at different parts on the multi-receptor
>> complex.) The other mechanism of action putatively results from the
>> effectalcoholhas on the various cell membranes, making them more
>> ****ous and more susceptible to slightly polar small molecules that
>> would normal not cross the membrane. Each of these mechanisms of
>> action has a different dosage dependent pharmacodynamic profile, and
>> lower doses seem to favor receptor mediated function, whereas higher
>> doses affect non-specific functions more. So based on the part of the
>> buzz that you like, you may like one part more than the other.
>>
>> There are also putative results suggesting that the brains of some
>> hardcore alcoholics are qualitatively different than those of non-
>> alcoholics, and that an opioidergic effect may be the reason (The THIQ
>> theory which has been suggested to be a result of the condensation
>> product of ethanol and dopamine, but this is not definitive.)
>>
>> There is also a difference in many people insofar as the way they
>> respond to acetaldehyde, the primary metabolite of ethanol. The
>> stomach has a larger percentage of the enzymeAlcoholDehydrogenase
>> (ADH or AlDH) when compared to the bloodstream and even the liver.
>> This is especially true in men compared to women and varies greatly
>> among different races, particularly orientals. The higher amounts of
>> acetaldehyde often change to feelingalcoholgives you, and this is
>> thought to be part of the biphasic response most people experience
>> fromalcohol(I am fairly certain that most of you have experienced
>> going to bed drunk and passing out, and then three hours later, waking
>> up still drunk with insomnia.) This is the biphasic response ofalcohol:
>> initially, it acts like a euphoriant and a sedative, but
>> later, it acts like a stimulant. This is likely related to the buildup
>> of acetaldehyde in your system, when amounts ofalcoholare lower. The
>> ratio ofalcoholto acetaldehyde, and possibly the ratio of
>> acetaldehyde's metabolite, acetate (aka acetic acid which is very
>> strong vinegar. Vinegar is between 3-5% acetic acid in water and other
>> goodies that impart flavor differences like sugar and tannins in
>> Balsamic Vinegar.)
>>
>> The point is that getting the right concentration ofalcoholmakes a
>> lot of difference. If you have food in your stomach, a neat Macallan
>> 25 may cause a much deeper euphoria than the same thing on an empty
>> stomach. High sugar fortified wines like ****ts may also affect you
>> differently and this is why they are drank at the end of a meal as
>> opposed to the beginning (plus they go better with chocolate than many
>> other wines like Chardonnay or Zinfandel. I also like a good Cognac
>> after dinner with a Cuban cigar, but a nice glass of 97 Taylor
>> Fladgate LBV with something chocolate works best or dessert.
>>
>> Mobi
>
> Thanks so much for the detailed reply Mobi, but can you please clarify
> which kind of wine gives the maximum amount of Euphoria? Thjere are
> hundreds of wines available in the supermarket,and a person doesn't
> have the time to go thru trial and error and find the right wine. Is
> it red or white wine? Which country?
> Which kind of wine in your experience produces the most euphoria?
> Thanks again and bye.
And whats wrong with trial and error
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